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Journal Club

公衆栄養学研究室では基礎栄養学研究室と合同で毎週(16:30~18:00),最新の栄養学に関するトピックを中心としたジャーナルクラブ(抄読会)を開催しています。

 

    【発表内容】
    研究テーマに関連する論文を紹介します。分野の異なる人にも理解してもらえるよう、研究の背景から結果の解釈までをわかりやすく紹介します。

    【発表形式】
    A4で5~7枚程度のレジュメを作成し、皆の前でプレゼンをします(目安時間;発表60分,質疑30分)。論文PDFを担当発表日1週間前に全員に送ります。

    【ジャーナルクラブをするメリット】
  • 適切な論文を選ぶ練習になる
  • 論文をきちんと読みこなす練習になる
  • 人に説明することで自分の頭が整理される
  • 広義の栄養学に関する最新の研究成果をメンバ全員で共有することができる
  • 発表(and 質問)のトレーニングになる

  • 【学生の感想】
    修士2年A氏の場合

     論文選び(過去5年以内に発行,日本人以外が著者,インパクトファクターが高いなどいくつか条件がある),レジュメ作成,分かりやすい紹介の仕方,質問対策など本番に備えて結構することが多く,時間のかかる課題だった。4回生の時は1ヶ月前には紹介する論文を決めていたが,院生になってからはこれまでに見つけた論文を紹介すればよいかと思い,1ヶ月前にようやく探しはじめるといった感じであった。そんな状態で自分の研究内容である日本食についての先行研究を調べていた時は,日本人が書いた論文ばかり手元にあり,「日本人が著者の論文はジャーナルクラブで紹介できない。やばい。」となってしまった。その結果,一からジャーナルクラブの論文を検索し,本番直前は準備に時間を取られ研究どころではなくなってしまったことがある。
     ジャーナルクラブは自分の研究と関連する論文の紹介が目的ではあるが,研究とは分かれた1つの課題として捉え,研究と同時並行で進めないといけない。(これから取り組む皆さんは気を付けてください。)
     ジャーナルクラブの論文を選ぶ作業や紹介時の聞き手からの質問を通して,論文の結果を鵜呑みにしないことが大切であることを痛感した。方法(特にサンプル数,解析手法)が適切かを判断し,結果の図表と結果の文章に相違がないかを確認する癖はジャーナルクラブを通して身に付けることができたと感じる。相手の論文紹介時にも内容を追うだけでなく,批判的に聞くことを心掛けていた。ただし,紹介された論文は発表者が書いたものではないので,自身が質問する際には鋭い質問をするというよりかは,発表者に自分が捉えた内容と合っているかを確認する,教えてもらう聞き方をするように心掛けていた。相手の発表や質疑応答を見聞きすることで,自分の知識や発表,質疑応答に足りないスキルを学ぶことができた。(2022/03)

    学部4年B氏の場合

     ここ公衆栄養学研究室は、どの研究室よりも英語の論文を読んでいると言う噂の研究室。
    私は英語が苦手だが、この研究室の研究内容が面白そうだと思い入ることを決意。いざ入ると初日から英語の論文を読まされた。おっとこれは語弊があるな、読まさせて頂いた。月日は流れ、今日はジャーナルクラブ初日。
     ジャーナルクラブとは基礎栄養学研究室と合同で行っている、研究に参考になりそうな最新の英語論文を紹介する会である。担当者は事前にレジュメを作り、皆に配布する。初日は基礎研の〇〇さん。3個上の先輩だ。 ジャーナルクラブは16時半から始まるのだが、それまでに事前に渡されたレジュメをよく読んでおく。レジュメを一通り見たがうーーーんわからない、全然わからない。もう1ページ目からわからない。初めて聞く単語ばかりだ。そんなこんなでジャーナルクラブが始まった。なぜか発表しないこちらまで少し緊張してくる。レジュメに沿って論文の説明をされているが、やはり実際に〇〇さんの説明を聞いてもわからないことが山ほどある。そんな時は「質問いいですか?」と手を挙げる。この言葉はとても便利だ。この言葉で発表者は一旦説明を中断し、こちらの質問に耳を傾け答えてくれる。最初はどのタイミングで言おう、と迷うかもしれない。しかし迷う必要は無い。わからないまま進んでしまうのでは無く、わからないことがあったらすぐ聞くことが重要だからだ。特に4回生は院生と比べて知識が浅いので怖がらずにどんなことでもたくさん質問すると良い。そんなこんなで〇〇さんの発表が終わり、月日が流れ自分の番がやって来た。
     事前に今井先生から、準備は思ってるより時間がかかるから早めに取りかかるようにと念を押されていた。私は1ヶ月ちょい前から取り掛かったが、それでもギリギリで、質問対策にほとんどとりかかれずに本番を迎えてしまった。もっと早めに始めればよかったと思ったが時すでにお寿司、いや遅し(苦笑)。そんな反省を生かし、後期は取り組んだ。しかし、後期のジャーナルクラブは研究真っ只中で行われるため、前期よりも大変だった。前期よりも早めに準備しておくと絶対に良い。
     ジャーナルクラブでは自分の研究以外の知識を得ることができ、また論文を深く読む方法が身に付きます。みんなの前で発表するという良い機会にもなりました。ありがとうございました。(2022/03)

    学部4年C氏の場合

    10人以上を前に話すのでとても緊張します。でも、どんな質問が来るのか、どんな風に答えるのか練習できて、先輩方のプレゼンも見ることができるので勉強になります。また、1人で読んでいたら分からないことも、プレゼンや質問によって聞くことができて理解しやすくなります。1年間参加してみて、難しくて、準備も大変で緊張しましたが、卒論発表はもっと緊張するので、いきなり卒論発表ではなくて、ジャーナルクラブでプレゼンや文章の要約、質疑応答を練習できてとても良い機会でした。(2022/03)


    一覧

    2023年度(前期;月曜 D2-309,後期;月曜 D2-309) 

        

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    日程 担当 掲載雑誌 タイトル
    Abstract和訳
    4/10(月) 水谷(D3)Practice International journal of molecular sciences
    2022 Dec 13;23(24):15860
    Ketogenic Diet Increases Serum and White Adipose Tissue SIRT1 Expression in Mice
    4/17(月) 加藤す(M2) British journal of nutrition
    2022 Jul 6;1-8.
    Two-day fasting affects kynurenine pathway with additional modulation of short-term whole-body cooling: a quasi-randomised crossover trial
    4/24(月) 後藤(M2) Free Radical Biology and Medicine
    2021 Nov 1;175:141-154
    Elevated branched-chain α-keto acids exacerbate macrophage oxidative stress and chronic inflammatory damage in type 2 diabetes mellitus
    5/8(月) 梅田(M2) Frontiers in immunology
    2021 Jun 4;12:678914
    Ischemia-Reperfusion Injury Reduces Kidney Folate Transporter Expression and Plasma Folate Levels
    5/22(月) 諸橋(M1) Nutrients
    2020 Jul 23;12(8):2185
    Time-Restricted Feeding Improves Body Weight Gain, Lipid Profiles, and Atherogenic Indices in Cafeteria-Diet-Fed Rats: Role of Browning of Inguinal White Adipose Tissue
    5/29(月) Yang BMJ Geriatrics
    2022 Apr 10;22(1):312
    The effects of vitamin D supplementation on frailty in older adults at risk for falls
    6/5(月) 村端(M1) J Am Geriatr Soc
    2019 Sep;67(9):1835-1842
    Prospective Associations of Diet Quality With Incident Frailty in Older Adults: The Health, Aging, and Body Composition Study
    6/12(月) 伊藤(B4) Nature
    2018 Nov;563(7731):354-359
    De novo NAD+ synthesis enhances mitochondrial function and improves health
    6/12(月) 浅田(B4) Diabetes Care
    2018 May;41(5):e83.
    Response to Comment on Li et al. Time Trends of Dietary and Lifestyle Factors and Their Potential Impact on Diabetes Burden in China. Diabetes Care 2017;40:1685-1694
    6/19(月) 田中あ(B4) Food Chem
    2023 Jan 1;398:133944
    In vitro bioaccessibility of vitamins B1, B2, and B3 from various vegetables
    6/19(月) 菊池(B4) BMJ Open
    2020 Aug 26;10(8):e037554
    Health impacts and environmental footprints of diets that meet the Eatwell Guide recommendations: analyses of multiple UK studies
    6/26(月) 魚谷(B4) Journal of Molecular Medicine
    2018 Nov;96(11):1203-1213
    High-fat diet consumption reduces hepatic folate transporter expression via nuclear respiratory factor-1
    6/26(月) 松浦(B4) Clinical Nutrition
    2021 Mar;40(3):919-927
    Animal protein intake reduces risk of functional impairment and strength loss in older adults
    7/3(月) 西川(B4) Nutrients
    2022 Dec 16;14(24):5345
    Riboflavin Intake Inversely Associated with Cardiovascular-Disease Mortality and Interacting with Folate Intake: Findings from the National Health and Nutrition Examination Survey (NHANES) 2005-2016
    7/3(月) 横山そ(B4) Cells
    2023 Feb 10;12(4):568
    Hepatic Nampt Deficiency Aggravates Dyslipidemia and Fatty Liver in High Fat Diet Fed Mice
    9/25(月) 水谷(D3) Biochem Biophys Res Commun
    2023 Sep 24;674:162-169
    Adipocyte NMNAT1 expression is essential for nuclear NAD+ biosynthesis but dispensable for regulating thermogenesis and whole-body energy metabolism
    10/2(月) 梅田(M2) Nephrol Dial Transplant
    2011 Jul;26(7):2137-44
    Effect of chronic kidney disease on the expression of thiamin and folic acid transporters
    10/16(月) 後藤(M2) BMC medicine
    2020 Nov 11;18(1):318
    Impact of the common MTHFR 677C→T polymorphism on blood pressure in adulthood and role of riboflavin in modifying the genetic risk of hypertension: evidence from the JINGO project
    10/23(月) 加藤(M2) Experimental gerontology
    2020 Feb 15:134:110880
    Kynurenine aminotransferase isoforms display fiber-type specific expression in young and old human skeletal muscle
    10/30(月) 諸橋(M1) Frontiers in nutrition.
    2023 Jan 9:9:1008730
    Ramadan diurnal intermittent fasting is associated with significant plasma metabolomics changes in subjects with overweight and obesity: A prospective cohort study
    11/6(月) 村端(M1) Public health nutrition
    2020 Sep;23(13):2384-2394
    More frequent cooking at home is associated with higher Healthy Eating Index-2015 score
    11/13(月) 浅田(B4) Lancet Public health
    2018 Dec;3(12):e576-e585
    The effect of socioeconomic deprivation on the association between an extended measurement of unhealthy lifestyle factors and health outcomes: a prospective analysis of the UK Biobank cohort
    11/13(月) 田中あ(B4) Heliyon.
    2022 Oct 14;8(10):e11061
    The effect of in vitro simulated gastrointestinal digestive system on the biodegradation of B group vitamins in bread
    11/20(月) 菊池(B4) The British journal of nutrition
    2023 Jul 14;130(1):83-92
    Prospective associations between diet quality and health-related quality of life in the Australian Diabetes, Obesity and Lifestyle (AusDiab) study
    11/20(月) 魚谷(B4) Genes & nutrition
    2014 Jan;9(1):369
    Reduced expression of folate transporters in kidney of a rat model of folate oversupplementation
    11/27(月) 松浦(B4) The journals of gerontology
    2020 Jan 20;75(2):348-356
    Prospective Associations Between Dietary Antioxidant Intake and Frailty in Older Australian Men: The Concord Health and Ageing in Men Project
    11/27(月) 伊藤(B4) Nature communications
    2022 Dec 8;13(1):7576
    The role of the tryptophan-NAD + pathway in a mouse model of severe malnutrition induced liver dysfunction
    12/4(月) 西川(B4) Journal of the Endocrine Society
    2021 Apr 20;5(6):bvab067
    Branched-Chain Amino Acids Associate Negatively With Postprandial Insulin Secretion in Recent-Onset Diabetes
    12/4(月) 横山そ(B4) Endocrinology.
    2021 Mar 1;162(3):bqab006
    Importance of Adipose Tissue NAD+ Biology in Regulating Metabolic Flexibility
    12/11(月) Yang Am J Physiol Endocrinol Metab
    2018 Apr 1;314(4):E377-E395
    Perturbations of NAD + salvage systems impact mitochondrial function and energy homeostasis in mouse myoblasts and intact skeletal muscle

    2022年度(前期;水曜 D2-309,後期;水曜 A7-102) 

        

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    日程 担当 掲載雑誌 タイトル
    Abstract和訳
    5/11(水) 水谷(D2) Am J Physiol Endocrinol Metab
    2018 Apr 1;314(4):E377-E395
    Perturbations of NAD + salvage systems impact mitochondrial function and energy homeostasis in mouse myoblasts and intact skeletal muscle
    5/18(水) 梅田(M1) Sci Signal
    2021 Nov 16;14(709):eabh3839.
    Thyroid hormone signaling promotes hepatic lipogenesis through the transcription factor ChREBP
    5/25(水) 加藤す(M1) Am J Clin Nutr
    2021 Nov 8;114(5):1646-1654
    Metabolomics of the tryptophan-kynurenine degradation pathway and risk of atrial fibrillation and heart failure: potential modification effect of Mediterranean diet
    6/1(水) 後藤(M1) Cardiovasc Diabetol
    2019 Jul 5;18(1):86.
    Impaired branched chain amino acid oxidation contributes to cardiac insulin resistance in heart failure
    6/15(水) 加藤は(B4) Int J Mol Sci
    2020 Jan 16;21(2):582.
    Influence of Sex on Urinary Organic Acids: A Cross-Sectional Study in Children
    6/15(水) 谷口(B4) Public Health Nutr
    2018 Apr;21(5):927-939
    Secular trends in regional differences in nutritional biomarkers and self-reported dietary intakes among American adults: National Health and Nutrition Examination Survey (NHANES) 1988-1994 to 2009-2010
    6/22(水) 光本(B4) J Aging Health
    2020;32(1):42-51
    Long Sleep Duration Is Associated With Increased Frailty Risk in Older Community-Dwelling Adults
    6/22(水) 諸橋(B4) Biochem J
    2003 Feb 1;369(Pt 3):687-95
    Investigation of potential mechanisms regulating protein expression of hepatic pyruvate dehydrogenase kinase isoforms 2 and 4 by fatty acids and thyroid hormone
    6/29(水) 坂(B4) Anal Chim Acta
    2018 Dec 11;1037:200-210
    Simultaneous determination of tryptophan and its 31 catabolites in mouse tissues by polarity switching UHPLC-SRM-MS
    6/29(水) 村端(B4) Nutrients
    2020 Nov; 12(11): 3263
    Beneficial Effect of Dietary Diversity on the Risk of Disability in Activities of Daily Living in Adults: A Prospective Cohort Study
    7/6(水) 西川(B4) Eur J Nutr
    2022 Feb;61(1):329-340.
    The female mouse is resistant to mild vitamin B 3 deficiency
    7/6(水) 山田(B4) Food Chem
    2021 Jul 15;350:129259
    Bioaccessibility of folate in faba bean, oat, rye and wheat matrices
    9/28(水) 加藤は(B4) J Crohns Colitis
    2020 Jun 19;14(5):595-607.
    Riboflavin Supplementation in Patients with Crohn's Disease [the RISE-UP study]
    10/5(水) 諸橋(B4) Sci Rep
    . 2017 Oct 26;7(1):14174.
    Effects of Supra-Physiological Levothyroxine Dosages on Liver Parameters, Lipids and Lipoproteins in Healthy Volunteers: A Randomized Controlled Crossover Study
    10/12(水) 坂(B4) Front Oncol
    2019 Sep 25;9:962.
    Resistance Exercise Reduces Kynurenine Pathway Metabolites in Breast Cancer Patients Undergoing Radiotherapy
    10/12(水) 谷口(B4) J Phys Act Health
    2021 Aug 1;18(S1):S37-S44.
    Trends in Meeting the Physical Activity Guidelines: Muscle-Strengthening Alone and Combined With Aerobic Activity, United States, 1998-2018
    10/19(水) 西川(B4) Nutrition
    2021 Jul-Aug;87-88
    Short-term nicotinamide riboside treatment improves muscle quality and function in mice and increases cellular energetics and differentiating capacity of myogenic progenitors
    10/19(水) 山田(B4) J Agric Food Chem
    2021 Apr 21;69(15):4402-4411.
    Impact of Cooking Preparation on In Vitro Digestion of Eggs Simulating Some Gastrointestinal Alterations in Elders
    11/2(水) 水谷(B4) Nutrients
    2022 May 28;14(11):2259
    Nicotinamide Riboside Supplementation to Suckling Male Mice Improves Lipid and Energy Metabolism in Skeletal Muscle and Liver in Adulthood
    11/2(水) 梅田(B4) Nutrients
    2020 Nov 17;12(11):3529
    Circulatory and Urinary B-Vitamin Responses to Multivitamin Supplement Ingestion Differ between Older and Younger Adults
    11/9(水) 加藤す(M1) Eur J Pharmacol
    2020 Sep 15;883:173363.
    Experimental hypothyroidism raises brain kynurenic acid - Novel aspect of thyroid dysfunction
    11/9(水) 後藤(M1) Clin Chem Lab Med
    2021 Jul 30;59(11):1824-1831
    Urine organic acids may be useful biomarkers for metabolic syndrome and its components in Korean adults
    11/16(水) 村端(B4) J Nutr
    2012 Dec;142(12):2112-8
    Diet quality is inversely related to cardiovascular risk factors in adults
    11/23(水) 光本(B4) J Nutr Health Aging
    . 2017;21(8):918-926.
    Multi-Domains Lifestyle Interventions Reduces Depressive Symptoms among Frail and Pre-Frail Older Persons: Randomized Controlled Trial

    2021年度  D2-309

                           
    日程 担当 掲載雑誌 タイトル
    Abstract和訳
    4/14(水) 水谷(D1) Sci Rep.
    2021.Mar 11;11(1):5637.
    Combined nicotinamide N-methyltransferase inhibition and reduced-calorie diet normalizes body composition and enhances metabolic benefits in obese mice
    4/21(水) 佐藤(M2) Alzheimers Dement.
    2017 Nov;13(11):1187-1196.
    The association between an inflammatory diet and global cognitive function and incident dementia in older women: The Women's Health Initiative Memory Study 28531379
    4/28(水) 宮前(M2) Brain Behav Immun.
    2018 Mar;69:321-335.
    Glia- and tissue-specific changes in the Kynurenine Pathway after treatment of mice with lipopolysaccharide and dexamethasone
    5/19(水) 加藤(B4) Int J Tryptophan Res.
    2019 Dec 17;12:1178646919891169.
    Lipopolysaccharide Increases Cortical Kynurenic Acid and Deficits in Reference Memory in Mice
    5/26(水) 西川(B4) Nutrients.
    2020 Oct 16;12(10):3156.
    Dietary Protein Intake Patterns and Inadequate Protein Intake in Older Adults from Four Countries 33081081
    6/9(水) 奥野(B4) J Nutr.
    2017 Nov;147(11):2025-2030. doi: 10.3945/jn.117.250852. Epub 2017 Sep 20.
    Leucine Transamination Is Lower in Middle-Aged Compared with Younger Adults
    6/16(水) 中村(B4) BMC Med.
    2021 Mar 16;19(1):64. doi: 10.1186/s12916-021-01918-5.
    Relationship between diet quality scores and the risk of frailty and mortality in adults across a wide age spectrum 33722232
    6/23(水) 梅田(B4) Front Pharmacol.
    2018 Feb 16;9:46. doi: 10.3389/fphar.2018.00046. eCollection 2018.
    Metabolomics Based Profiling of Dexamethasone Side Effects in Rats
    6/30(水) 徳丸(B4) J Am Geriatr Soc.
    2020 Apr;68(4):770-776. doi: 10.1111/jgs.16286. Epub 2019 Dec 16.
    Association between Diet Quality and Frailty Prevalence in the Physicians' Health Study 31840808
    7/7(水) 後藤(B4) Redox Biol.
    2018 Jul;17:89-98. doi: 10.1016/j.redox.2018.04.006. Epub 2018 Apr 5.
    Nicotinamide riboside attenuates alcohol induced liver injuries via activation of SirT1/PGC-1α/mitochondrial biosynthesis pathway
    7/14(水) 滝口(M1) PLoS One.
    2021 Feb 16;16(2):e0245630. doi: 10.1371/journal.pone.0245630. eCollection 2021.
    Poor diet quality is associated with self-reported knee pain in community-dwelling women aged 50 years and older 33591989
    10/28(水) 徳丸(B4) J Hum Hypertens.
    2020 Feb;34(2):132-142. doi: 10.1038/s41371-019-0231-x. Epub 2019 Aug 21.
    The association of dietary phosphorus with blood pressure: results from a secondary analysis of the PREMIER trial 31435005
    10/28(水) 中村(B4) J Acad Nutr Diet.
    2018 Nov;118(11):2120-2127. doi:10.1016/j.jand.2018.05.026. Epub 2018 Aug 23.
    Recognition of Federal Dietary Guidance Icons Is Associated with Greater Diet Quality 30146482
    11/4(水) 梅田(B4) Int J Mol Sci.
    2019 Jun 26;20(13):3122. doi: 10.3390/ijms20133122.
    Proteomic Analysis of Morphologically Changed Tissues after Prolonged Dexamethasone Treatment
    奥野(B4) Nutrients.
    2019 Aug 13;11(8):1882. doi: 10.3390/nu11081882.
    Of Older Mice and Men: Branched-Chain Amino Acids and Body Composition
    11/11(水) 加藤(B4) Am J Physiol Cell Physiol.
    2016 May 15;310(10):C836-40. doi:10.1152/ajpcell.00053.2016. Epub 2016 Mar 30.
    Endurance exercise increases skeletal muscle kynurenine aminotransferases and plasma kynurenic acid in humans
    西川(B4) Am J Clin Nutr
    2021 Sep 1;114(3):1141-1147. doi: 10.1093/ajcn/nqab144.
    Association between meal-specific daily protein intake and lean mass in older adults: results of the cross-sectional BASE-II study 33963728
    11/18(水) 後藤(B4) Hum Genomics.
    2019 Dec 10;13(1):65. doi: 10.1186/s40246-019-0251-1.
    Investigating RNA expression profiles altered by nicotinamide mononucleotide therapy in a chronic model of alcoholic liver disease
    11/25(水) 滝口(M1) Nutrients.
    2021 Jun 24;13(7):2168. doi: 10.3390/nu13072168.
    Usual Protein Intake Amount and Sources of Nursing Home Residents with (Risk of) Malnutrition and Effects of an Individualized Nutritional Intervention: An enable Study 34202567
    12/2(水) 宮前(M2) JCI Insight.
    2020 Jul 23;5(14):e140327. doi: 10.1172/jci.insight.140327.
    COVID-19 infection alters kynurenine and fatty acid metabolism, correlating with IL-6 levels and renal status
    12/9(水) 佐藤(M2) Int J Epidemiol
    2019 Dec 1;48(6):1914-1924. doi: 10.1093/ije/dyz196.
    Dietary n-3 polyunsaturated fatty acids, fish intake and healthy ageing 31563961
    12/16(水) 水谷(D1)

    2020年度(前期;Zoom  後期;D2-309) 

              
    日程 担当 掲載雑誌 タイトル
    Abstractの和訳
    5/28(木) 田中(M2) Clin Nutr.
    2020 Nov;39(11):3369-3376
    Cluster analysis of nutritional factors associated with low muscle mass index in middle-aged and older adults 32192777
    水谷(M2) PLoS One.
    2019 Feb 22;14(2):e0212523
    NAMPT overexpression alleviates alcohol- induced hepatic steatosis in mice
    6/4(木) 小泉(M2) Cells.
    2020 Feb 1;9(2):341.
    Metabolomic Analysis of the Liver of a Dextran Sodium Sulfate-Induced Acute Colitis Mouse Model: Implications of the Gut-Liver Connection
    平井(M2) Am J Physiol Endocrinol Metab.
    2019 Apr 1;316(4):E660-E673.
    Glucose and amino acid metabolism in mice depend mutually on glucagon and insulin receptor signaling
    6/11(木) 佐藤(M1) Clin Nutr.
    2019 Apr;38(2):682-688.
    Dietary inflammatory potential and risk of mortality in metabolically healthy and unhealthy phenotypes among overweight and obese adults 29705061
    宮前(M1) J Neurochem.
    2017 Jan;140(1):68-81.
    Maternal protein restriction during gestation and lactation in the rat results in increased brain levels of kynurenine and kynurenic acid in their adult offspring
    6/18(木) 松野(M1) Am J Clin Nutr.
    2003 Apr;77(4):847-56.
    Summary measure of dietary musculoskeletal nutrient (calcium, vitamin D, magnesium, and phosphorus) intakes is associated with lower-extremity physical performance in homebound elderly men and women 12663282
    6/25(木) 滝口(B4) J Gerontol A Biol Sci Med Sci.
    2016 Mar;71(3):356-61.
    Dietary Protein Intake Is Protective Against Loss of Grip Strength Among Older Adults in the Framingham Offspring Cohort 26525088
    諌本(B4) Microchem J.
    Determination and assessment of the bioaccessibility of vitamins B₁, B₂, and B₃ in commercially available cereal-based baby foods
    7/2(木) 辻(B4) Am J Clin Nutr.
    2017 Oct;106(4):1032-1040.
    Intake of niacin, folate, vitamin B-6, and vitamin B-12 through young adulthood and cognitive function in midlife: the Coronary Artery Risk Development in Young Adults (CARDIA) study 28768650
    森(B4) Am J Physiol Gastrointest Liver Physiol.
    2016 Feb 15;310(4):G285-93.
    Conditional (intestinal-specific) knockout of the riboflavin transporter-3 (RFVT-3) impairs riboflavin absorption
    7/16(木) 矢吹(B4) Cell Mol Gastroenterol Hepatol.
    2020;9(4):557-567.
    Biotin Supplementation Ameliorates Murine Colitis by Preventing NF-κB Activation
    7/30(木) 相宮(B4) Mol Psychiatry.
    2019 Oct;24(10):1523-1532.
    Leucine competes with kynurenine for blood-to-brain transport and prevents lipopolysaccharide-induced depression-like behavior in mice
    松井(B4) J Clin Med.
    2019 Nov 12;8(11):1948.
    Urinary Excretion of N1-Methylnicotinamide, as a Biomarker of Niacin Status, and Mortality in Renal Transplant Recipients
    中川(B4) Nutrients.
    2018 Sep 23;10(10):1363.
    Association between the Dietary Inflammatory Index and Risk of Frailty in Older Individuals with Poor Nutritional Status
    10/1(木) 田中(M2) J Nutr.
    2020 Oct 12;150(10):2789-2798.
    Lower Dietary and Circulating Vitamin C in Middle- and Older-Aged Men and Women Are Associated with Lower Estimated Skeletal Muscle Mass 32851397
    水谷(M2) Int J Mol Sci.
    2019 Dec 24;21(1):142
    The Lifespan Extension Ability of Nicotinic Acid Depends on Whether the Intracellular NAD + Level Is Lower than the Sirtuin-Saturating Concentrations
    10/8(木) 小泉(M2) Mol Med.
    2018 Mar 15;24(1):3.
    Uncoupling of glycolysis from glucose oxidation accompanies the development of heart failure with preserved ejection fractions
    平井(M2) Front Physiol.
    2019 Sep 4;10:1140
    BCAA Catabolic Defect Alters Glucose Metabolism in Lean Mice
    10/15(木) 佐藤(M1) Nutrients.
    2018 Feb 7;10(2):182.
    Lower Dietary Inflammatory Index Scores Are Associated with Lower Glycemic Index Scores among College Students 29414858
      宮前(M1) Biol Psychiatry.
    2017 Nov 15;82(10):756-765.
    Adaptive and Behavioral Changes in Kynurenine 3-Monooxygenase Knockout Mice: Relevance to Psychotic Disorders
    10/29(木) 矢吹(B4) Cell Physiol Biochem.
    2018;50(6):2272-2282.
    Mice Deficient in Cyp4a14 Have An Increased Number of Goblet Cells and Attenuated Dextran Sulfate Sodium-Induced Colitis
      中川(B4) Br J Nutr.
    2015 Oct 14;114(7):1088-98.
    Dietary factors and biomarkers of systemic inflammation in older people: the Lothian Birth Cohort 1936
    11/5(木) 辻(B4) Am J Clin Nutr
    2014 Feb;99(2):320-7.
    High dietary phosphorus intake is associated with all-cause mortality: results from NHANES III 24225358
    森(B4) Dig Dis Sci.
    2019 Jan;64(1):84-92.
    Sodium Butyrate Enhances Intestinal Riboflavin Uptake via Induction of Expression of Riboflavin Transporter-3 (RFVT3)
    11/12(木) 滝口(B4) Front Nutr.
    2020 Mar 16;7:25.
    Amount, Source and Pattern of Dietary Protein Intake Across the Adult Lifespan: A Cross-Sectional Study 32232047
    松井(B4) Biochim Biophys Acta Mol Cell Biol Lipids.
    2020 Feb;1865(2):158543.
    Increased fatty acid oxidation and mitochondrial proliferation in liver are associated with increased plasma kynurenine metabolites and nicotinamide levels in normolipidemic and carnitine-depleted rats
    12/3(木) 相宮(B4) Exp Biol Med (Maywood).
    2017 Apr;242(7):750-761.
    The activation of the kynurenine pathway in a rat model with renovascular hypertension
    諌本(B4) Food Chem.
    2016 Oct 15;209:177-84.
    Protein oxidation and proteolysis during storage and in vitro digestion of pork and beef patties

    2019年度(D4-302)

    日程 担当 掲載雑誌 タイトル
    4/15(月) 井上(M2) Exp Mol Med.
    2019 Feb 13;51(2):1-14.
    Kynurenine 3-monooxygenase is a critical regulator of renal ischemia-reperfusion injury
    4/22(月) 鬼頭(M2) Nutrients.
    2018 Jan 31;10(2):162.
    Dietary Balance Index-07 and the Risk of Anemia in Middle Aged and Elderly People in Southwest China: A Cross Sectional Study
    5/27(月) 小泉(M1) Front Microbiol.
    2019 Jan 8;9:3260.
    Bacillus amyloliquefaciens Ameliorates Dextran Sulfate Sodium-Induced Colitis by Improving Gut Microbial Dysbiosis in Mice Model
    6/3(月) 平井(M1) Dig Dis Sci.
    2019 Jan;64(1):84-92.
    Sodium Butyrate Enhances Intestinal Riboflavin Uptake via Induction of Expression of Riboflavin Transporter-3 (RFVT3)
    水谷(M1) Cell Rep.
    2018 Oct 30;25(5):1359-1370.e4.
    Alpha-Amino-Beta-Carboxy-Muconate-Semialdehyde Decarboxylase Controls Dietary Niacin Requirements for NAD + Synthesis
    6/10(月) 衣川(B4) Front Pharmacol.
    2019 Feb 6;10:79.
    Evaluation of Riboflavin Transporters as Targets for Drug Delivery and Theranostics
    佐藤桂(B4) Public Health Nutr.
    2014 Aug;17(8):1689-96.
    Designing and developing a literature-derived, population-based dietary inflammatory index
    6/17(月) 田中(M1) Br J Nutr.
    2016 Aug;116(4):666-76.
    Dietary scores at midlife and healthy ageing in a French prospective cohort
    上坊(B4) Clin Nutr.
    2020 Apr;39(4):1077-1084.
    Associations between dietary patterns at age 71 and the prevalence of sarcopenia 16 years later
    7/8(月) 佐藤未(B4) EMBO Mol Med.
    2017 May;9(5):571-588.
    Niacin ameliorates ulcerative colitis via prostaglandin D 2-mediated D prostanoid receptor 1 activation
    松野(B4) Clin Nutr.
    2017 Feb;36(1):267-274.
    Nutritional status, body composition, and quality of life in community-dwelling sarcopenic and non-sarcopenic older adults: A case-control study
    7/22(月) 奥田(B4) Nutrients.
    2018 Dec 1;10(12):1860.
    The Effect of a High-Dose Vitamin B Multivitamin Supplement on the Relationship between Brain Metabolism and Blood Biomarkers of Oxidative Stress: A Randomized Control Trial
    宮前(B4) Transl Psychiatry.
    2019 Jan 29;9(1):37.
    Peripheral and central levels of kynurenic acid in bipolar disorder subjects and healthy controls
    9/30(月) 鬼頭(M2)(M2) Nutrients
    2018 Sep 13;10(9):1297.
    An Active Lifestyle Reinforces the Effect of a Healthy Diet on Cognitive Function: A Population-Based Longitudinal Study
    井上(M2) J Neuroinflammation.
    2018 Jan 4;15(1):3.
    Role of the indoleamine-2,3-dioxygenase/kynurenine pathway of tryptophan metabolism in behavioral alterations in a hepatic encephalopathy rat model
    10/7(月) 上坊(B4) Osteoporos Int.
    2016 Nov;27(11):3251-3260.
    Measurements of skeletal muscle mass and power are positively related to a Mediterranean dietary pattern in women
    10/21(月) 奥田(B4) N Engl J Med.
    2016 May 5;374(18):1754-62.
    Ozanimod Induction and Maintenance Treatment for Ulcerative Colitis
    佐藤桂(B4) Am J Clin Nutr.
    2015 Dec;102(6):1534-42.
    Association of habitual dietary resveratrol exposure with the development of frailty in older age: the Invecchiare in Chianti study
    10/28(月) 松野(B4) Age Ageing.
    2018 Nov 1;47(6):872-879.
    Low vitamin intake is associated with risk of frailty in older adults
    佐藤未(B4) Int J Mol Sci.
    2019 Aug 19;20(16):4048.
    Sorafenib-Induced Apoptosis in Hepatocellular Carcinoma Is Reversed by SIRT1
    11/11(月) 衣川(B4) Am J Physiol Gastrointest Liver Physiol.
    2017 Dec 1;313(6):G589-G598.
    Role of MicroRNA-423-5p in posttranscriptional regulation of the intestinal riboflavin transporter-3
    宮前(B4) Sci Rep.
    2017 Mar 7;7:43859.
    Microbiota alteration is associated with the development of stress-induced despair behavior
    11/18(月) 小泉(M1) Front Immunol.
    2018 May 14;9:701.
    Reactive Oxygen Species Deficiency Due to Ncf1-Mutation Leads to Development of Adenocarcinoma and Metabolomic and Lipidomic Remodeling in a New Mouse Model of Dextran Sulfate Sodium-Induced Colitis
    水谷(M1) PLoS Genet.
    2017 May 30;13(5):e1006819.
    Downregulation of SIRT1 signaling underlies hepatic autophagy impairment in glycogen storage disease type Ia
    12/2(月) 田中(M1) Nutrients.
    2018 Feb 17;10(2):226.
    Patterns of Protein Food Intake Are Associated with Nutrient Adequacy in the General French Adult Population
    平井(M1) Nutrients.
    2019 Feb 8;11(2):355.
    Impaired Skeletal Muscle Branched-Chain Amino Acids Catabolism Contributes to Their Increased Circulating Levels in a Non-Obese Insulin-Resistant Fructose-Fed Rat Model

    2018年度

    日程 担当 掲載雑誌 タイトル
    5/28(月) 鬼頭(M1) Am J Clin Nutr.
    2017 Feb;105(2):503-512
    Associations of dietary, lifestyle, and sociodemographic factors with iron status in Chinese adults: a cross-sectional study in the China Health and Nutrition Survey
    6/4(月) 井上(M1) Transl Psychiatry.
    2016 Oct 18;6(10):e918.
    Neurotoxic kynurenine metabolism is increased in the dorsal hippocampus and drives distinct depressive behaviors during inflammation
    6/11(月) 森(B4) Nutrients.
    2015 Sep 9;7(9):7562-79.
    Food Habits, Lifestyle Factors and Mortality among Oldest Old Chinese: The Chinese Longitudinal Healthy Longevity Survey (CLHLS)
    水谷(B4) Sci Rep.
    2013 Oct 17;3:2973.
    Prostaglandin E₂ is critical for the development of niacin-deficiency-induced photosensitivity via ROS production
    6/25(月) 田中(B4) JAMA Intern Med.
    2016 Oct 1;176(10):1453-1463.
    Association of Animal and Plant Protein Intake With All-Cause and Cause-Specific Mortality
    西村(B4) Nutrients.
    2017 Jun 29;9(7):676.
    Comparable Performance Characteristics of Plasma Thiamine and Erythrocyte Thiamine Diphosphate in Response to Thiamine Fortification in Rural Cambodian Women
    7/2(月) 村木(B4) Stroke.
    2012 Feb;43(2):335-40.
    Total antioxidant capacity of diet and risk of stroke: a population-based prospective cohort of women
    西野(B4) Eur J Nutr.
    2017 Jun;56(4):1767-1782.
    Foods contributing to vitamin B 6, folate, and vitamin B 12 intakes and biomarkers status in European adolescents: The HELENA study
    7/9(月) 福西(B4) Biochim Biophys Acta.
    2016 Nov;1860(11 Pt A):2345-2354.
    Tryptophan 2,3-dioxygenase and indoleamine 2,3-dioxygenase 1 make separate, tissue-specific contributions to basal and inflammation-induced kynurenine pathway metabolism in mice
    平井(B4) J Nutr.
    2016 Jan;146(1):14-20.
    A Vitamin B-6 Antagonist from Flaxseed Perturbs Amino Acid Metabolism in Moderately Vitamin B-6-Deficient Male Rats
    7/23(月) 小泉(B4) Am J Physiol Gastrointest Liver Physiol.
    2014 Feb 15;306(4):G320-7.
    Therapeutic role of niacin in the prevention and regression of hepatic steatosis in rat model of nonalcoholic fatty liver disease
    10/1(月) 井上(M1) Sci Rep.
    2016 Jul 20;6:29920.
    Depressive symptoms as a side effect of Interferon-α therapy induced by induction of indoleamine 2,3-dioxygenase 1
    10/15(月) 鬼頭(M1) J Nutr Health Aging.
    2015 Nov;19(9):935-40.
    The Relationship between Anemia, Hemoglobin Concentration and Frailty in Brazilian Older Adults
    10/22(月) 福西(B4) J Neuroinflammation.
    2016 May 27;13(1):124.
    Kynurenine metabolic balance is disrupted in the hippocampus following peripheral lipopolysaccharide challenge
    村木(B4) Eur J Clin Nutr.
    2016 Jan;70(1):109-15.
    Coffee consumption and risk of hypertension in the Polish arm of the HAPIEE cohort study
    10/29(月) 水谷(B4) Cell Metab.
    2016 Aug 9;24(2):269-82.
    Loss of NAD Homeostasis Leads to Progressive and Reversible Degeneration of Skeletal Muscle
    田中(B4) PLoS One.
    2016 Mar 23;11(3):e0151596.
    Mediterranean Diet and Health-Related Quality of Life in Two Cohorts of Community-Dwelling Older Adults
    11/5(月) 西村(B4) Food Funct.
    2015 Jan;6(1):242-8.
    Folate bioavailability from foods rich in folates assessed in a short term human study using stable isotope dilution assays
    11/12(月) 小泉(B4) Hepatology.
    2017 Feb;65(2):616-630.
    Nicotinamide adenine dinucleotide biosynthesis promotes liver regeneration
    西野(B4) Am J Clin Nutr.
    2015 Jun;101(6):1163-72.
    Impact of voluntary fortification and supplement use on dietary intakes and biomarker status of folate and vitamin B-12 in Irish adults
    11/19(月) 平井(B4) Sports Med Open.
    2017 Dec;3(1):14.
    A Placebo-Controlled Trial of Riboflavin for Enhancement of Ultramarathon Recovery

    2017年度

    日程 担当 掲載雑誌 タイトル
    6/5(月) 牧野(M2) J Nutr.
    2015 Jan;145(1):79-86.
    Obesity is associated with increased red blood cell folate despite lower dietary intakes and serum concentrations
    6/19(月) 大原(M2) Mol Nutr Food Res.
    2017 Aug;61(8):1600878.
    Effects of a wide range of dietary nicotinamide riboside (NR) concentrations on metabolic flexibility and white adipose tissue (WAT) of mice fed a mildly obesogenic diet
    6/26(月) 井上(B4) Pharmacol Rep.
    2014 Jun;66(3):466-70.
    Modulation by kynurenine of extracellular kynurenate and glutamate in cerebral cortex of rats with acute liver failure
    7/3(月) 井川(B4) Br J Nutr.
    2015 Sep 28;114(6):915-23.
    A high energy intake from dietary fat among middle-aged and older adults is associated with increased risk of malnutrition 10 years later
    7/10(月) 鬼頭(B4) Am J Clin Nutr.
    2008 May;87(5):1298-305.
    Relationship between iron status and dietary fruit and vegetables based on their vitamin C and fiber content
    7/24(月) 柴田(B4) Soc Sci Med.
    2016 Oct;167:37-44.
    Decomposing trends in adult body mass index, obesity, and morbid obesity, 1971-2012
    7/31(月) 田崎(B4) Am J Physiol Gastrointest Liver Physiol.
    2014 Feb 15;306(4):G320-7.
    Therapeutic role of niacin in the prevention and regression of hepatic steatosis in rat model of nonalcoholic fatty liver disease

    2016年度

    日程 担当 掲載雑誌 タイトル
    6/15(水) 浦田(M2) J Neurosci.
    2008 Jul 30;28(31):7863-75.
    TRPA1 channels mediate cold temperature sensing in mammalian vagal sensory neurons: pharmacological and genetic evidence
    6/29(水) 黒木(M2) J Neurosci.
    2015 Aug 19;35(33):11634-43.
    Alcohol Elicits Functional and Structural Plasticity Selectively in Dopamine D1 Receptor-Expressing Neurons of the Dorsomedial Striatum
    牧野(M1) J Epidemiol.
    2008;18(3):125-31.
    Serum folate and methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism adjusted for folate intake
    7/27(水) 大原(M1) J Neuroinflammation.
    2014 Dec 13;11:204.
    Quinolinic acid toxicity on oligodendroglial cells: relevance for multiple sclerosis and therapeutic strategies
    8/3(水) 楠本(M1) Brain Behav Immun.
    2015 Aug;48:165-73.
    Gut microbiota depletion from early adolescence in mice: Implications for brain and behaviour
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